The Role of Transrectal Power Doppler Imaging in the Detection of Prostate Cancer: a Preliminary Study

The Role of Transrectal Power Doppler Imaging in the Detection of Prostate Cancer: a Preliminary Study
PropertyValue
Title:The Role of Transrectal Power Doppler Imaging in the Detection of Prostate Cancer: a Preliminary Study
Author/Abstract:Sigrid M. Agcaoili, MD; Bryian C. Pineda-Paner, MD; Debourrah Levi D. Hernando, MD; Ivy Rosales, MD; Marcelino M. Morales Jr., MD; Ferdinand Morabe, MD; Arnold Joseph Fernandez, MD and Hermenegildo Jose B. Zialcita, MD

Department of Urology, National Kidney and Transplant Institute


Objective: This study aimed to evaluate the clinical utility of power Doppler ultrasonography (PDUS) in the detection of prostate cancer and determine its predictive ability compared to digital rectal examination, serum PSA levels and gray-scale transrectal ultrasonography, using biopsy as the reference standard. Materials and Methods: This is a cross-sectional study of 49 consecutive patients who underwent prostate needle biopsies at the National Kidney and Transplant Institute. All patients were seen at the Out-patient Department, suspected of having prostate cancer because of abnormally high serum PSA levels (>4 ng/ml) and/or abnormal digital rectal examination. Patients previously diagnosed with prostate cancer were excluded in the study. All patients underwent gray-scale TRUS before power Doppler imaging of the prostate using the Siemens Sonoline Elegra high resolution digital ultrasound with a 6.5 MHz endocavitary probe. After power Doppler imaging, a systematic 12-core and lesion-directed TRUS-guided biopsy of the prostate was performed. Results: A total of 49 patients (mean age 64.45, SD 7.53, range 41-79) were included in this study. Prostate needle biopsy confirmed 15 (30.6%) to have prostate cancer. Of the 15 patients diagnosed with prostate cancer, 5 (33.3%) had an abnormal DRE, 10 (66.7%) had abnormal TRUS findings, 3 (20%) had positive power Doppler flow. PDUS has a positive predictive value of 60% and a specificity of 94.1%. Conclusion: The overall prostate cancer detection rate is 30.6% with a sensitivity of 66.7% for gray-scale TRUS and 20% for power Doppler ultrasonography. PDUS increased the predictive value and specificity of Gray-scale TRUS.

Key words: prostate cancer, power Doppler ultrasonography, gray-scale transrectal ultrasonography
Filesize: 89.25 kB
Filetype:pdf (Mime Type: application/pdf)