Enzyme PRSS3 Linked To Aggressive Prostate Cancer

FG_AUTHORS: Medical News Today

Editor's Choice
Academic Journal
Main Category: Prostate / Prostate Cancer
Also Included In: Urology / Nephrology;  Cancer / Oncology
Article Date: 29 Dec 2012 - 2:00 PST

Current ratings for:
Enzyme PRSS3 Linked To Aggressive Prostate Cancer

Healthcare Prof:Enzyme PRSS3 Linked To Aggressive Prostate Cancer

An enzyme, known as PRSS3, is specifically associated with aggressive prostate cancer risk, researchers from the Mayo Clinic, Florida reported this week in the journal Molecular Cancer Research.

The scientists, who claim they are the first to link the enzyme to prostate cancer, added that they have developed a compound that can stop PRSS3 from encouraging metastasis - when cancer spreads beyond its point of origin to other parts of the body.

Senior investigator, Evette Radisky, Ph.D., a cancer biologist, said:

"This molecule is a protease, which means it digests other molecules. Our data suggests PRSS3 activity changes the environment around prostate cancer cells - perhaps by freeing them from surrounding tissue - to promote malignancy and invasiveness.

I don't think PRSS3 is the only factor involved in driving aggressive prostate cancer, but it may be significant for a certain subset of this cancer - the kind that is potentially lethal."

Dr. Radisky and team had set out to determine, from data on previous clinical trials which had information on molecules that are irregularly switched on in cancer, which enzymes encouraged metastasis.

In a previous study they had identified a link between the protease and the initial stages of breast cancer.

They wanted to find out whether any other cancer abnormally expresses this protease, and when. They gathered and analyzed data from several sources.

A protease is an enzyme that breaks down proteins and peptides.

Dr. Radisky said:

"The link between PRSS3 activity and aggressive prostate cancer jumped out at us. We found a definitive trend of increasing PRSS3 expression with cancer progression."

In an animal experiment using mice with prostate cancer, they showed that protease expression was vital for prostate cancer metastasis. When PRSS3 was silenced, the cancer did not spread.

The team had previously crystallized the structure of the PRSS3 protease, and identified a place on the enzyme where a small protein therapeutic could bind to plug up the "scissoring" action of the molecule.

Dr Radisky said "The protease has an active site that breaks down other proteins, and our inhibiting agent sticks to the site, shutting it down."

The authors believe their breakthrough could pave the way for "several possible future clinical applications".

Prostate cancer patients could be tested for the presence of the enzyme, so that doctors could identify which ones had the highest risk of metastasis, Dr Radisky added.

The team have developed a "prototype drug", which they say provides a template upon which an agent could be used to treat patients with aggressive prostate cancer. Dr. Radisky said:

"Our inhibitor does not have the characteristics we need for a clinically useful drug. But it puts us on the right path to develop one."

Written by Christian Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

Visit our prostate / prostate cancer section for the latest news on this subject.
"PRSS3/Mesotrypsin Is a Therapeutic Target for Metastatic Prostate Cancer"
Evette Radisky, Ph.D.
doi: 10.1158/1541-7786.MCR-12-0314 Mol Cancer Res December 2012 10; 1555
Please use one of the following formats to cite this article in your essay, paper or report:


n.p. "Enzyme PRSS3 Linked To Aggressive Prostate Cancer." Medical News Today. MediLexicon, Intl., 29 Dec. 2012. Web.
29 Dec. 2012. <http://www.medicalnewstoday.com/articles/254495.php>


Please note: If no author information is provided, the source is cited instead.

'Enzyme PRSS3 Linked To Aggressive Prostate Cancer'Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.

If you write about specific medications or operations, please do not name health care professionals by name.

All opinions are moderated before being included (to stop spam)

Contact Our News Editors

For any corrections of factual information, or to contact the editors please use our feedback form.

Please send any medical news or health news press releases to:

Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.

Read more http://www.medicalnewstoday.com/articles/254495.php

PUA Social Network

Twitter Facebook

Contact us

The Philippine Urological Association,Inc
3rd floor. PCS Bldg., 992 EDSA, Quezon City,
Metro Manila, PHILIPPINES 1105
View Map


eMail us